Whisk together Worcestershire sauce, soy sauce, smoked paprika, honey, black pepper, red pepper flakes, garlic powder, and onion powder in a large bowl. Add beef; mix until completely coated with marinade. Cover the bowl with plastic wrap and marinate in the refrigerator, 3 hours to overnight.

Preheat the oven to 175 degrees F (80 degrees C). Line a baking sheet with aluminum foil and place a wire rack on top.

Transfer beef to paper towels to dry. Discard marinade.

Arrange beef slices in a single layer on the prepared wire rack on the baking sheet.

Bake in the preheated oven until dry and leathery, 3 to 4 hours.

Cut jerky with scissors into bite-sized pieces.