Gather all ingredients. Preheat the oven to 500 degrees F (260 degrees C).

Mix flour and Greek yogurt together in a bowl to form a dough; transfer to a work surface floured with self-rising flour.

Knead dough, adding more flour as needed to keep dough from being too sticky, about 8 to 10 minutes.

Spray a 12-inch pizza pan with cooking spray and spread dough to the edges of the pan.

Bake pizza crust in preheated oven for 5 to 7 minutes; add your favorite toppings and return to the preheated oven.

Bake until crust is lightly browned, 5 to 7 minutes more.